Evaluation of the need for biopsy in a pediatric population with suspected Celiac clinical disease
The aim was to evaluate the diagnosis value of serological tests in a pediatric population with suspected celiac disease. In the serum of patients with classical symptoms, non-classical symptoms, or with an increased risk for celiac disease, antibodies anti–tissue transglutaminase IgA (a-tTG-IgA) an...
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| Формат: | Online |
| Язык: | Spanish |
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Facultad de Ciencias Exactas, Químicas y Naturales
2017
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| Online-ссылка: | https://www.fceqyn.unam.edu.ar/recyt/index.php/recyt/article/view/206 |
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ojs-article-2062020-03-06T10:56:19Z Evaluation of the need for biopsy in a pediatric population with suspected Celiac clinical disease Evaluación de la necesidad de biopsia en una población pediátrica con sospecha clínica de Celiaquía López, Miryan S. Fermoselle, Gianninna Manulak, María A. Sprang, Mónica D. R. Vinuesa, Fernando Zapata, Pedro D. Negri, Gustavo A. Celiac disease Tissue transglutaminasa Antibodies Deamidated gliadin peptide Biopsy Enfermedad celíaca Transglutaminasa tisular Anticuerpos Péptidos deaminados de gliadina Biopsia The aim was to evaluate the diagnosis value of serological tests in a pediatric population with suspected celiac disease. In the serum of patients with classical symptoms, non-classical symptoms, or with an increased risk for celiac disease, antibodies anti–tissue transglutaminase IgA (a-tTG-IgA) and IgG anti–deamidated gliadin peptide (a-DGP-IgG) were measured. Endoscopic biopsy was performed on 97 patients: 62 of them had Marsh 3 lesion (celiac disease confirmed), 7 had Marsh 2 lesion and the other 28, Marsh 0-1 lesion. A 100% of positive predictive value for a tTG-IgA ≥ 100 U ml, and 95% for a-DGP-IgG ≥ 100 U/ml were obtained. When both (tTG-IgA and a-DGP-IgG) were ≤ 10 U/ml, the negative predictive value was 100%. Values of a-tTG-IgA ≥ 100 U/ml allowed the diagnosis of celiac disease in the studied population. When a-tTG-IgA and a-DGP-IgG, were both ≤ 10 U/ml it ruled out celiac disease. Nuestro objetivo fue evaluar el valor diagnóstico de pruebas serológicas de enfermedad celíaca en poblaciones pediátricas con sospecha clínica de celiaquía. En el suero de los pacientes con síntomas clásicos, no clásicos o pertenecientes a grupos de riesgo de celiaquía se dosaron anticuerpos anti-transglutaminasa tisular de tipo IgA (a-tTG-IgA) y anticuerpos contra los péptidos deaminados de gliadina de tipo IgG (a-DGP-IgG). Fueron biopsiados 97 pacientes: 62 presentaron histología Marsh 3 (enfermedad celíaca confirmada), 7 histología Marsh 2 y 28 histología Marsh 0-1. Se obtuvo valor predictivo positivo 100% para valores de a-tTG-IgA ≥ 100 U/ml y 96% para a-DGP-IgG ≥ 100 U/ml. Cuando ambos anticuerpos fueron ≤ 10 U/ml se obtuvo valor predictivo negativo 100%. En nuestro estudio, los anticuerpos a-tTG-IgA permitieron el diagnóstico de celiaquía cuando su valor fue ≥ 100 U/ ml. Cuando a-tTG-IgA y a-DGP-IgG fueron ambos ≤ 10 U/ml se pudo descartar enfermedad celíaca. Facultad de Ciencias Exactas, Químicas y Naturales 2017-12-20 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.fceqyn.unam.edu.ar/recyt/index.php/recyt/article/view/206 Argentine Journal of Science and Technology; Vol. 28 No. 1 (2017); 63-69 Revista de Ciencia y Tecnología; Vol. 28 Núm. 1 (2017); 63-69 1851-7587 0329-8922 spa https://www.fceqyn.unam.edu.ar/recyt/index.php/recyt/article/view/206/295 |
| institution |
Facultad de Ciencias Exactas Quimicas y Naturales |
| collection |
Revista de Ciencia y Tecnologia RECyT |
| language |
Spanish |
| topic |
Celiac disease Tissue transglutaminasa Antibodies Deamidated gliadin peptide Biopsy Enfermedad celíaca Transglutaminasa tisular Anticuerpos Péptidos deaminados de gliadina Biopsia |
| spellingShingle |
Celiac disease Tissue transglutaminasa Antibodies Deamidated gliadin peptide Biopsy Enfermedad celíaca Transglutaminasa tisular Anticuerpos Péptidos deaminados de gliadina Biopsia López, Miryan S. Fermoselle, Gianninna Manulak, María A. Sprang, Mónica D. R. Vinuesa, Fernando Zapata, Pedro D. Negri, Gustavo A. Evaluation of the need for biopsy in a pediatric population with suspected Celiac clinical disease |
| topic_facet |
Celiac disease Tissue transglutaminasa Antibodies Deamidated gliadin peptide Biopsy Enfermedad celíaca Transglutaminasa tisular Anticuerpos Péptidos deaminados de gliadina Biopsia |
| format |
Online |
| author |
López, Miryan S. Fermoselle, Gianninna Manulak, María A. Sprang, Mónica D. R. Vinuesa, Fernando Zapata, Pedro D. Negri, Gustavo A. |
| author_facet |
López, Miryan S. Fermoselle, Gianninna Manulak, María A. Sprang, Mónica D. R. Vinuesa, Fernando Zapata, Pedro D. Negri, Gustavo A. |
| author_sort |
López, Miryan S. |
| title |
Evaluation of the need for biopsy in a pediatric population with suspected Celiac clinical disease |
| title_short |
Evaluation of the need for biopsy in a pediatric population with suspected Celiac clinical disease |
| title_full |
Evaluation of the need for biopsy in a pediatric population with suspected Celiac clinical disease |
| title_fullStr |
Evaluation of the need for biopsy in a pediatric population with suspected Celiac clinical disease |
| title_full_unstemmed |
Evaluation of the need for biopsy in a pediatric population with suspected Celiac clinical disease |
| title_sort |
evaluation of the need for biopsy in a pediatric population with suspected celiac clinical disease |
| title_alt |
Evaluación de la necesidad de biopsia en una población pediátrica con sospecha clínica de Celiaquía |
| description |
The aim was to evaluate the diagnosis value of serological tests in a pediatric population with suspected celiac disease. In the serum of patients with classical symptoms, non-classical symptoms, or with an increased risk for celiac disease, antibodies anti–tissue transglutaminase IgA (a-tTG-IgA) and IgG anti–deamidated gliadin peptide (a-DGP-IgG) were measured. Endoscopic biopsy was performed on 97 patients: 62 of them had Marsh 3 lesion (celiac disease confirmed), 7 had Marsh 2 lesion and the other 28, Marsh 0-1 lesion. A 100% of positive predictive value for a tTG-IgA ≥ 100 U ml, and 95% for a-DGP-IgG ≥ 100 U/ml were obtained. When both (tTG-IgA and a-DGP-IgG) were ≤ 10 U/ml, the negative predictive value was 100%. Values of a-tTG-IgA ≥ 100 U/ml allowed the diagnosis of celiac disease in the studied population. When a-tTG-IgA and a-DGP-IgG, were both ≤ 10 U/ml it ruled out celiac disease. |
| publisher |
Facultad de Ciencias Exactas, Químicas y Naturales |
| publishDate |
2017 |
| url |
https://www.fceqyn.unam.edu.ar/recyt/index.php/recyt/article/view/206 |
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