Enteropathogenic Escherichia Coli: influence of subinhibitory concentrations of ciprofloxacin on associated-virulence factors
In this study, we investigated the influence of subinhibitory concentrations of ciprofloxacin on enteropathogenic Escherichia coli (EPEC) virulence factors as motility, adherence, hemolysin production and the interaction with some mechanisms of host defenses (phagocytosis)...
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Facultad de Ciencias Exactas, Químicas y Naturales
2005
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| Online Access: | https://www.fceqyn.unam.edu.ar/recyt/index.php/recyt/article/view/421 |
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ojs-article-4212020-03-06T00:42:46Z Enteropathogenic Escherichia Coli: influence of subinhibitory concentrations of ciprofloxacin on associated-virulence factors Escherichia Coli enteropatógena: influencia de concentraciones subinhibitorias de ciprofloxacina sobre factores asociados al a virulencia Quiroga, M. Oviedo, P. Pegels, E. Husulak, E. Jordá, G. Ortíz, A. Ruttler, M. E. Vergara, M. Escherichia coli ciprofloxacin virulence diarrhea Escherichia coli ciprofloxacina virulencia diarrea In this study, we investigated the influence of subinhibitory concentrations of ciprofloxacin on enteropathogenic Escherichia coli (EPEC) virulence factors as motility, adherence, hemolysin production and the interaction with some mechanisms of host defenses (phagocytosis). Adherence was investigated on bfp gene. The detection of bfp was reduced on 22% of the strains with 1/2 and 1/8 MIC, and on 11% of the strains with 1/4 and 1/16 MIC. We did not observe relevant differences on the hemolysin poduction, motility reduction or phagocytosis reduction on any of the studied strains. In view of these results, it could be important to continue with this kind of studies in order to optimize simple therapeutic schemes for the treatment of uncomplicated infections, reducing the adverse reactions of some drugs on the host. En este estudio, investigamos la influencia de concentraciones subinhibitorias de ciprofloxacina sobre factores de virulencia de Escherichia coli enteropatógeno (ECEP) como la movilidad, adherencia, producci´ón de hemolisinas y la interacción con algunos mecanismos de defensa del huésped (fagocitosis). La adherencia se investigó sobre el gen bfp. La detección de bfp disminuyo un 22% de las cepas con 1/2 y 1/8 de CIM, y en 11% de las cepas con 1/4 y 1/16 de CIM. No observamos diferencias significativas en la producción de hemolisinas, reducción de la movilidad o de la fagocitosis en ninguna de las cepas ensayadas. Dado estos resultados, sería importante continuar con este tipo de estudios a fin de optimizar esquemas terapéuticos simples para el tratamiento en las infecciones no complicadas, disminuyendo las reacciones adversas que puedan algunas drogas ocasionar en el huésped. Facultad de Ciencias Exactas, Químicas y Naturales 2005-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.fceqyn.unam.edu.ar/recyt/index.php/recyt/article/view/421 Argentine Journal of Science and Technology; Vol. 7 No. 1 (2005); 28-36 Revista de Ciencia y Tecnología; Vol. 7 Núm. 1 (2005); 28-36 1851-7587 0329-8922 spa https://www.fceqyn.unam.edu.ar/recyt/index.php/recyt/article/view/421/344 Derechos de autor 2005 Revista de Ciencia y Tecnología |
| institution |
Facultad de Ciencias Exactas Quimicas y Naturales |
| collection |
Revista de Ciencia y Tecnologia RECyT |
| language |
Spanish |
| topic |
Escherichia coli ciprofloxacin virulence diarrhea Escherichia coli ciprofloxacina virulencia diarrea |
| spellingShingle |
Escherichia coli ciprofloxacin virulence diarrhea Escherichia coli ciprofloxacina virulencia diarrea Quiroga, M. Oviedo, P. Pegels, E. Husulak, E. Jordá, G. Ortíz, A. Ruttler, M. E. Vergara, M. Enteropathogenic Escherichia Coli: influence of subinhibitory concentrations of ciprofloxacin on associated-virulence factors |
| topic_facet |
Escherichia coli ciprofloxacin virulence diarrhea Escherichia coli ciprofloxacina virulencia diarrea |
| format |
Online |
| author |
Quiroga, M. Oviedo, P. Pegels, E. Husulak, E. Jordá, G. Ortíz, A. Ruttler, M. E. Vergara, M. |
| author_facet |
Quiroga, M. Oviedo, P. Pegels, E. Husulak, E. Jordá, G. Ortíz, A. Ruttler, M. E. Vergara, M. |
| author_sort |
Quiroga, M. |
| title |
Enteropathogenic Escherichia Coli: influence of subinhibitory concentrations of ciprofloxacin on associated-virulence factors |
| title_short |
Enteropathogenic Escherichia Coli: influence of subinhibitory concentrations of ciprofloxacin on associated-virulence factors |
| title_full |
Enteropathogenic Escherichia Coli: influence of subinhibitory concentrations of ciprofloxacin on associated-virulence factors |
| title_fullStr |
Enteropathogenic Escherichia Coli: influence of subinhibitory concentrations of ciprofloxacin on associated-virulence factors |
| title_full_unstemmed |
Enteropathogenic Escherichia Coli: influence of subinhibitory concentrations of ciprofloxacin on associated-virulence factors |
| title_sort |
enteropathogenic escherichia coli: influence of subinhibitory concentrations of ciprofloxacin on associated-virulence factors |
| title_alt |
Escherichia Coli enteropatógena: influencia de concentraciones subinhibitorias de ciprofloxacina sobre factores asociados al a virulencia |
| description |
In this study, we investigated the influence of subinhibitory concentrations of ciprofloxacin on enteropathogenic Escherichia coli (EPEC) virulence factors as motility, adherence, hemolysin
production and the interaction with some mechanisms of host defenses (phagocytosis). Adherence was investigated on bfp gene. The detection of bfp was reduced on 22% of the strains with 1/2 and 1/8 MIC, and on 11% of the strains with 1/4 and 1/16 MIC. We did not observe relevant differences on the hemolysin poduction, motility reduction or phagocytosis reduction on any of the studied strains. In view of these results, it could be important to continue with this kind of studies in order to
optimize simple therapeutic schemes for the treatment of uncomplicated infections, reducing the adverse reactions of some drugs on the host. |
| publisher |
Facultad de Ciencias Exactas, Químicas y Naturales |
| publishDate |
2005 |
| url |
https://www.fceqyn.unam.edu.ar/recyt/index.php/recyt/article/view/421 |
| work_keys_str_mv |
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