Antifungal Formulation Based on Saturated Sucrose Solution: Evaluation of its potential genotoxic activity using the Allium cepa test
In the present study, the potential genotoxicity effects of the antifungal formulation based on saturated sucrose solution were evaluated employing the Allium cepa test. Five exposure times were evaluated, mineral water was used as negative control, and experiments were carried out in duplicate. For...
| Main Authors: | , , |
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| Format: | Online |
| Language: | Spanish |
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Facultad de Ciencias Exactas, Químicas y Naturales
2012
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| Subjects: | |
| Online Access: | https://www.fceqyn.unam.edu.ar/recyt/index.php/recyt/article/view/471 |
| _version_ | 1814554261024931840 |
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| author | Bich, Gustavo A. Vedoya, María C. Medvedeff, Martha G. |
| author_facet | Bich, Gustavo A. Vedoya, María C. Medvedeff, Martha G. |
| author_sort | Bich, Gustavo A. |
| collection | Revista de Ciencia y Tecnologia RECyT |
| description | In the present study, the potential genotoxicity effects of the antifungal formulation based on saturated sucrose solution were evaluated employing the Allium cepa test. Five exposure times were evaluated, mineral water was used as negative control, and experiments were carried out in duplicate. For statistical analysis, one-way analysis of variance (ANOVA) and Tukey HSD post-test were used (statistical significance α = 0.05). Frequencies of chromosomal abnormalities ranged from 0% to 0.24%. We conclude that the antifungal formulation based on sucrose saturated solution did not present a significant genotoxic activity, considering the results of the present study involving the Allium cepa test. |
| format | Online |
| id | ojs-article-471 |
| institution | Facultad de Ciencias Exactas Quimicas y Naturales |
| language | Spanish |
| publishDate | 2012 |
| publisher | Facultad de Ciencias Exactas, Químicas y Naturales |
| record_format | ojs |
| spelling | ojs-article-4712020-03-06T10:53:59Z Antifungal Formulation Based on Saturated Sucrose Solution: Evaluation of its potential genotoxic activity using the Allium cepa test Formulación antifúngica basada en solución saturada de sacarosa: evaluación de su potencial actividad genotóxica empleando la prueba de Allium cepa Bich, Gustavo A. Vedoya, María C. Medvedeff, Martha G. Saturated sucrose solution Allium cepa test Genotoxic activity Solución saturada de sacarosa Prueba de Allium cepa Actividad genotóxica In the present study, the potential genotoxicity effects of the antifungal formulation based on saturated sucrose solution were evaluated employing the Allium cepa test. Five exposure times were evaluated, mineral water was used as negative control, and experiments were carried out in duplicate. For statistical analysis, one-way analysis of variance (ANOVA) and Tukey HSD post-test were used (statistical significance α = 0.05). Frequencies of chromosomal abnormalities ranged from 0% to 0.24%. We conclude that the antifungal formulation based on sucrose saturated solution did not present a significant genotoxic activity, considering the results of the present study involving the Allium cepa test. En el presente trabajo, los potenciales efectos genotóxicos de la formulación antifúngica basada en la solución saturada de sacarosa fueron evaluados utilizando la Prueba de Allium cepa. Se evaluaron por duplicado cinco tiempos de exposición empleando agua mineral como control. Para el análisis estadístico, se empleó un análisis de varianza (ANOVA) y una prueba a-posteriori de Tukey HSD (significación estadística α = 0,05). Las frecuencias de las anomalías cromosómicas observadas partieron desde 0% a 0,24% y el análisis estadístico de las frecuencias de anomalías cromosómicas reveló que no se detectaron diferencias estadísticamente significativas en relación con los controles. Se concluye que la formulación antifúngica en base a solución saturada de sacarosa no evidenció una actividad genotóxica al evaluarse los resultados del presente trabajo empleando la prueba de Allium cepa. Facultad de Ciencias Exactas, Químicas y Naturales 2012-12-20 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.fceqyn.unam.edu.ar/recyt/index.php/recyt/article/view/471 Argentine Journal of Science and Technology; Vol. 18 No. 1 (2012); 39-43 Revista de Ciencia y Tecnología; Vol. 18 Núm. 1 (2012); 39-43 1851-7587 0329-8922 spa https://www.fceqyn.unam.edu.ar/recyt/index.php/recyt/article/view/471/391 Derechos de autor 2012 Revista de Ciencia y Tecnología |
| spellingShingle | Saturated sucrose solution Allium cepa test Genotoxic activity Solución saturada de sacarosa Prueba de Allium cepa Actividad genotóxica Bich, Gustavo A. Vedoya, María C. Medvedeff, Martha G. Antifungal Formulation Based on Saturated Sucrose Solution: Evaluation of its potential genotoxic activity using the Allium cepa test |
| title | Antifungal Formulation Based on Saturated Sucrose Solution: Evaluation of its potential genotoxic activity using the Allium cepa test |
| title_alt | Formulación antifúngica basada en solución saturada de sacarosa: evaluación de su potencial actividad genotóxica empleando la prueba de Allium cepa |
| title_full | Antifungal Formulation Based on Saturated Sucrose Solution: Evaluation of its potential genotoxic activity using the Allium cepa test |
| title_fullStr | Antifungal Formulation Based on Saturated Sucrose Solution: Evaluation of its potential genotoxic activity using the Allium cepa test |
| title_full_unstemmed | Antifungal Formulation Based on Saturated Sucrose Solution: Evaluation of its potential genotoxic activity using the Allium cepa test |
| title_short | Antifungal Formulation Based on Saturated Sucrose Solution: Evaluation of its potential genotoxic activity using the Allium cepa test |
| title_sort | antifungal formulation based on saturated sucrose solution evaluation of its potential genotoxic activity using the allium cepa test |
| topic | Saturated sucrose solution Allium cepa test Genotoxic activity Solución saturada de sacarosa Prueba de Allium cepa Actividad genotóxica |
| topic_facet | Saturated sucrose solution Allium cepa test Genotoxic activity Solución saturada de sacarosa Prueba de Allium cepa Actividad genotóxica |
| url | https://www.fceqyn.unam.edu.ar/recyt/index.php/recyt/article/view/471 |
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