Resistance Mechanisms Associated with Treatment with Tyrosine Kinase Inhibitors in Philadelphia Positive Leukemias

Resistance Mechanisms Associated with Treatment with Tyrosine Kinase Inhibitors in Philadelphia Positive Leukemias

The BCR::ABL1 chimeric gene is implicated in the pathogenesis of chronic myeloid leukemia (CML), but the precise molecular mechanisms that initiate leukemogenesis remain challenging to identify. Currently, the treatment of CML is based on tyrosine kinase inhibitors (TKIs) targeting the chimeric onco...

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Bibliographic Details
Main Author: Ferri, Cristian A.
Format: Online
Language:English
Published: Facultad de Ciencias Exactas, Químicas y Naturales 2024
Subjects:
Chronic Myeloid Leukemia
Tyrosine Kinase Inhibitors
Mutations
BCR-ABL1-Independent Resistance Mechanisms
Leucemia Mieloide Crónica
Inhibidores de Tirosina Quinasa
Mutaciones
Mecanismos de Resistencia Independientes de BCR-ABL
Online Access:https://www.fceqyn.unam.edu.ar/recyt/index.php/recyt/article/view/802

Internet

https://www.fceqyn.unam.edu.ar/recyt/index.php/recyt/article/view/802

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